Immunoinformatics Study on Early 4 Protein of Human Papillomavirus Type 16 for Cervical Cancer Vaccine Peptide Candidate

Yani Suryani(1*), Opik Taupiqurrohman(2), Muhammad Yusuf(3), Toto Subroto(4), Sukma Nuswantara(5)

(1) Department of Biology Faculty of Science and Technology UIN Sunan Gunung Djati Bandung, Indonesia
(2) Department of Biology Faculty of Science and Technology UIN Sunan Gunung Djati Bandung, Indonesia
(3) Department of Chemistry Faculty of Math and Science University of Padjadjaran, Indonesia
(4) Department of Chemistry Faculty of Math and Science University of Padjadjaran, Indonesia
(5) Pusat Penelitian Bioteknologi, Jl. Raya Jakarta-Bogor No. 46 Km Cibinong, Bogor, West Java 16911,  
(*) Corresponding Author


 The aims of this study were to carry out testing of the early 4 protein of type 16 HPV through immunoinformatics meth-ods in an effort to get the peptide vaccine candidate for cervical cancer. The software used are IEDB-AR, CABSdock and Accelrys Discovery Study 4.5. Based on the analysis that sequence of ami-no acid lysine, leucine, leucine, glycine, serine, threonine, tryp-tophan, proline and threonine (KLLGSTWPT) and the sequence of amino acid tyrosine, tyrosine, valine, leucine, histidine, leucine, cysteine, leucine, alanine, alanine, threonine, lysine, tyrosine, pro-line and leucine (YYVLHLCLAATKYPL) are peptide vaccine can-didate for cervical cancer from the early 4 protein of HPV type 16 


cervical cancer, Early 4, Human papillomavirus, immunoinformatics, vaccine

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