Senyawa Isoflavonoid Terisoprenilasi dari Ranting Flemingia macrophylla

Authors

  • Issaora Juni Annisa Tiara Kasih Ria Halim Departemen Kimia, Fakultas Sains dan Teknologi, Universitas Airlangga, Indonesia
  • Mulyadi Tanjung Departemen Kimia, Fakultas Sains dan Teknologi, Universitas Airlangga, Indonesia
  • Ratih Dewi Saputri Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Negeri Surabaya, Indonesia
  • Muhamad Fajar Aldin Departemen Kimia, Fakultas Sains dan Teknologi, Universitas Airlangga, Indonesia
  • Tjittik Srie Tjahjandarie Departemen Kimia, Fakultas Sains dan Teknologi, Universitas Airlangga, Indonesia

DOI:

https://doi.org/10.15575/ak.v8i1.8711

Keywords:

Flemingia macrophylla, isoflavonoid, 8-(1.1-dimethyl-prop-2-enyl) genistein, osajin, anticancer.

Abstract

Flemingia macrophylla merupakan tumbuhan perdu yang termasuk keluarga Fabaceae. Senyawa fenolik Flemingia mengandung senyawa flavonoid dan isoflavonoid. Penelitian ini bertujuan untuk menentukan aktivitas sitotoksik senyawa isoflavonoid dari Flemingia macrophylla terhadap sel kanker payudara T47D. Ekstraksi dan isolasi senyawa isoflavonoid menggunakan metanol pada suhu kamar. Dua senyawa isoflavonoid terisoprenilasi, 8-(1.1-dimetil-prop-2-enil) genistein (1) dan osajin (2) telah berhasil dipisahkan dari ranting Flemingia macrophylla. Penentuan struktur senyawa isoflavonoid menggunakan data spektroskopi ultraviolet (UV), inframerah (IR), 1D dan 2D NMR. Sitotoksik 8-(1.1-dimetil-prop-2-enil) genistein (1) dan osajin (2) terhadap sel kanker payudara T47D memperlihatkan nilai IC50 sebesar 10,91 ± 0,17 dan 3,72 ± 0,23 µg/mL.

Author Biography

Issaora Juni Annisa Tiara Kasih Ria Halim, Departemen Kimia, Fakultas Sains dan Teknologi, Universitas Airlangga

Departemen Kimia

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Published

2021-06-30

Issue

Vol. 8 No. 1 (2021): al Kimiya: Jurnal Ilmu Kimia dan Terapan

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Articles

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