Naphthalene Derivates from Bawang Tiwai Bulb Eleutherine Bulbosa in Borneo

Authors

  • Supriatno Salam Faculty of Pharmacy, Universitas Mulawarman, Samarinda Department of Chemistry, Faculty of Science and Mathematics, Sultan Idris Education Universiti, Tg Malim 35900, Perak, Malaysia. https://orcid.org/0000-0002-0486-6763
  • Baso Didik Hikmawan Universitas Mulawarman, Indonesia
  • Erwin Samsul Universitas Mulawarman, Indonesia
  • Herman Herman Universitas Mulawarman, Indonesia
  • Islamudin Ahmad Universitas Mulawarman, Indonesia
  • Laode Rijai Universitas Mulawarman, Indonesia
  • Mohd Azlan Nafiah Sultan Idris Education Universiti, Malaysia

DOI:

https://doi.org/10.15575/ak.v11i1.35515

Keywords:

Eleutherine bulbosa, Eleutherol, Eleutherol C, T47D breast cancer, East Kalimantan.

Abstract

Naphthalene derivative compounds named Eleutherol (1) and Eleutherol C (2) have been isolated from Bawang Tiwai Bulb Eleutherine bulbosa. We tested its cytotoxic activity against T47D breast cancer cells in vitro after isolating compounds 1 and 2 from the EtOH extract using conventional chromatography methods. Their chemical structures were elucidated based on spectroscopic analysis, including IR, HR-TOFMS, 1D, and 2D NMR, and by comparison to those related spectra previously reported. Compounds 1 and 2 were tested for their cytotoxic effects against T47D breast cancer cells and showed moderate cytotoxicity against T47D breast cancer cells with IC50 values of 117.15 and 80.21 µM, respectively, compared with cisplatin 24.07 µM.

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Published

2024-08-01

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Vol. 11 No. 1 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan

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